Prozac versus placebo. New studies say that for many people antidepressants may not work much better than sugar pills. We’ll hear the debate.

The President’s new budget means big changes at NASA: Private spaceships. No moon shot. Is this the way forward, or an American retreat from space?

We’ll talk with American Olympians and look ahead to the Vancouver Winter Games, opening one week from today.

Toyota turmoil. Big bonus plans. And the Joint Chiefs Chairman takes a stand on gay rights. Our weekly news roundtable goes behind the headlines.

We’ll get up close with the largest, loudest, longest-lived animals on earth with Philip Hoare, author of “The Whale.”

Pulitzer Prize-winning military writer Tom Ricks on the Pentagon, “Don’t Ask, Don’t Tell,” and the state of America’s wars in Afghanistan and Iraq.

We talk with Eve Ensler — author of “The Vagina Monologues” — about her tough new look at the lives of teenage girls around the world.

With filibuster threats and gridlock, many fear Congress is failing to deliver, just when the country needs it. We look at what’s been called the “broken branch.”

The reclusive life and classic work of “Catcher in the Rye” author J.D. Salinger — dead at 91.

“Avatar” was bumped off screens in China by a state-sponsored biopic on Confucius. We look at his teachings — and the rise of Confucianism in China today.

The Oscar buzz says it’s a big year for Hollywood women. We look past the hype with The New York Times’ Manohla Dargis and The Daily Beast’s Nicole LaPorte.

Call her country, call her rock, Lucinda Williams made her name singing about heartache. Now she’s found love. We check in with her, and her Grammy-nominated album, “Little Honey.”